Semisynthetic aminoglycoside antibiotics. III. New deoxy derivatives of paromomycin.
نویسندگان
چکیده
منابع مشابه
Semisynthetic aminoglycoside antibiotics. II. Synthesis of analogues of paromomycin modified in the glucosamine moiety.
Sir: The accomplishment of an efficient method for obtaining the previously unknown 1,3,2"',6"'tetra-N-acetylparomomycin (1) and the subsequent preparation of the pseudotrisaccharide 5-0[3-0(2,6-diami no-2,6-dideoxy-f-L-idopyranosyl)-/3-L-ribo-furanosyl]-2-deoxystreptamine(5), as described in the preceding papery, by nitrous acid deamination, suggested a route for providing a useful intermediat...
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BB-K 8, a new semisynthetic aminoglycosidic antibiotic, was evaluated for ototoxicity, nephrotoxicity and neuromuscular blocking activity in the cat. As a reference, kanamycin was tested by the same experimental methods. Employing equivalent doses in terms of the free base and 7 days of intraperitoneal treatment, BB-K8 and kanamycin were found to be similarly ototoxic and nephrotoxic. Acutely, ...
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RNA molecules have key roles in many essential biological processes, including protein synthesis, transcriptional regulation, mRNA splicing and retroviral replication. The structural diversity of RNA, together with the lack of known RNA repair mechanisms, make RNA a challenging and important target for therapeutic intervention [1]. Our understanding of the modes by which RNA is recognized by li...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1981
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.34.240